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Myalgische Enzephalomyelitis/Chronisches Fatigue-Syndrom (ME/CFS) ist eine Multisystemerkrankung mit verheerenden Folgen. Seit Jahrzehnten wird sie immer noch missverstanden, sie ist kaum erforscht und vom Gesundheitssystem kaum anerkannt. Der Dokumentarfilm erklärt die Erkrankung und schildert den Leidensweg von Betroffenen.